Here, we found a new regulator of GO transport, Syd, which is the homolog of the mammalian JIP3 in Drosophila. JIP3/Syd is involved in the axonal organelle transport, such as that of lysosomes (Gowrishankar et al., 2017) and early endosomes (Abe et al., 2009), and defects of the JIP3-dependent axonal lysosome transport aggravate Aβ accumulation in an AD model (Gowrishankar et al., 2017). The gene discussed is MAPK8IP3; the disease is Alzheimer disease.