LRRK2 and Parkinson disease: Recently, dendritic pathology related to GOs has been studied in a variety of neurodegenerative diseases: LRRK2 mutation, one of the pathogenic factors in Parkinson’s disease, suppresses dendrite arborization by regulating GO dynamics (Lin et al., 2015); also, nuclear polyglutamine (polyQ), a putative factor in Machado-Joseph’s disease, induces a defective terminal dendrite elongation by impairing GOs synthesis (Chung et al., 2017).