On the other hand, most of the T cells in the hu-PBL hIL-4 NOG mice exhibited a memory phenotype (CD45RO+CD45RA− fraction in Fig. S2 in the Supplementary material), while the B cells exhibited a plasmablast phenotype (CD27+CD38+ fraction in Fig. S2 in the Supplementary material), as shown in Fig. 1B. The CD8+ T cell/CD45+ cell proportion among the naïve fraction of HD-derived PBMCs tended to be higher than that among the BC-derived PBMCs (Fig. 1A, TN CD4, and CD8). The gene discussed is CD4; the disease is breast cancer.