ERBB2 and neoplasm: In this model, accounting for age, tumor size, nodal status, ER, PR, HER2, grade, LVI, chemotherapy and radiation, the presence of PNI remained significantly associated with LRR and the effect size was potentiated beyond that seen on univariate analysis (HR 1.57, 95% CI 1.2–2.07, p = 0.001).