These findings were paralleled by increased expression of claudin-2 and decreases in occludin in duodenal biopsies and a trend towards increased eosinophil degranulation suggesting that at least 50%–60% of IBS patients may have a nonclassical food allergy in which CLE can be used to dynamically monitor impairment of the intestinal barrier19. The gene discussed is OCLN; the disease is irritable bowel syndrome.