To investigate how the expression level of a delivered gene changed during disease progression of ALS, histological analysis was performed on spinal cords of SOD1(G93A) mice at 0 week as pre-symptomatic state, 6 weeks as mid stage of disease and 10 weeks as end stage of disease, after BMT (Fig. 4). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.