First, human U1-70K gene was found to accumulate in several cancer-types such as breast cancer (breast tumor luminal, HER2 positive breast carcinoma and triple-negative breast cancer), colon cancer (colon adenocarcinoma and colon mucinous adenocarcinoma) and rectal cancer (rectal cell carcinoma and rectal mucinous adenocarcinoma) (Fig. S9). Here, ERBB2 is linked to breast carcinoma.