We further analyzed two independent Gene Expression Omnibus (GEO) databases (GSE86237 and GSE54791)36,37, and we found that PHB was significantly increased in GSCs relative to BTCs (Fig. 1f) or the matched differentiated glioma cells (DGCs) (Supplementary Fig. 1f), supporting the upregulation of PHB in GSCs. This evidence concerns the gene PHB1 and central nervous system cancer.