Because fibroblasts undergo significant changes during the fibrotic progress in keloid (Fig. 1g), and fibroblasts are important for fibrotic pathogenesis, we next performed unsupervised clustering on all keloid and normal scar fibroblasts and observed further heterogeneity with 13 subclusters, sC1 through sC13 (Fig. 2a). This evidence concerns the gene CST11 and keloid.