Considering that one of the primary features of mesenchymal fibroblasts in keloid was abnormal ECM proteins expression including POSTN, and that POSTN-ITGAV;ITGB5 interactions between mesenchymal and other fibroblasts were significantly increased in keloid compared to normal scar, we next explored the function of mesenchymal fibroblasts on keloid fibroblast collagen expression. Here, ITGB5 is linked to keloid.