BCL11B, ERG, and CDK6 were expressed in these T-ALL samples (Supplementary Figs. 4c and 5a, b), and ChIP-seq analysis of blast cells from case 077, Jurkat and Loucy cells did confirm that the elements associated with the neo-loops were marked by H3K27ac, a sign for active enhancers (Fig. 5a–c). Here, BCL11B is linked to acute lymphoblastic leukemia.