The transcription factor BRN2, also known as POU3F2 and N-OCT3, plays a critical role in neurogenesis and drives proliferation in a range of cancer types with neural or neuroendocrine origins, including glioblastoma, neuroblastoma, small cell lung cancer, and neuroendocrine prostate cancer8–10. The gene discussed is POU3F2; the disease is glioblastoma.