Although the reduction of Brn2 in Braf-Pten-Brn2 primary melanoma is not sufficient to re-induce Mitf mRNA and pigmentation in all cells of these primary melanomas, the Braf-Pten melanoma cells that formed LN metastases were pigmented and re-expressed Sox10, a key transcription activator of Mitf. This evidence concerns the gene BRAF and melanoma.