The transcription factor BRN2, also known as POU3F2 and N-OCT3, plays a critical role in neurogenesis and drives proliferation in a range of cancer types with neural or neuroendocrine origins, including glioblastoma, neuroblastoma, small cell lung cancer, and neuroendocrine prostate cancer8–10. Here, POU3F2 is linked to small cell lung carcinoma.