POU3F2 and melanoma: Consistent with the observation that MITF and BRN2 are frequently observed in mutually exclusive populations in melanoma, and that BRN2 may act in vivo as an MITF repressor13, we have observed that in a non-tumoral context, the specific knock-out of Brn2 in vivo in melanocytes increases the level of Mitf (publication in preparation).