Moreover, from the GO, WikiPathways and KEGG 2019 analyses of the mouse melanoma tumors, the immune system (cytokine, neutrophil, macrophage) and angiogenesis are induced in Braf-Pten-Brn2-het tumors compared to Braf-Pten-Brn2-WT tumors (Supplementary Fig. 5A–C). The gene discussed is POU3F2; the disease is melanoma.