CDKN2A and melanoma: We next evaluated the concomitant BRN2 locus alterations, BRAF/NRAS mutations, and CDKN2A/PTEN alterations and found the most frequent genetic constellation that co-occurs with BRN2 loss in melanoma to be BRAFV600X mutation together with mono-allelic PTEN loss (Supplementary Fig. 2E).