On one hand, Braf-Pten-Brn2-het and Braf-Pten-Brn2-hom melanomas proliferate faster, and on the other hand, according to our results (Fig. 4F,G) Braf-Pten-Brn2-hom melanomas have a reduced ability to invade compared to Braf-Pten-Brn2-het melanomas. The gene discussed is PTEN; the disease is melanoma.