HOXC9 and obesity due to melanocortin 4 receptor deficiency: Notably, HOXC9 (an indicator of a beneficial metabolic phenotype and protector against obesity-related insulin resistance)70 was upregulated in RAD (~3.28 TPM) and SATs (ASA: ~5.10 TPM; ULB: ~1.21 TPM; ILB: ~1.17 TPM) compared to GOM (~0.14 TPM) and MAD (~0.22 TPM) (Supplementary Fig. 29b, c).