ACE2, the SARS-CoV-2 receptor required for cell entry in humans91 and a target of diabetes therapy, was specifically upregulated in the SATs of pigs (TPM = ~184.31) compared to those of other species (TPM = ~0.49); knockout of this PCG can worsen inflammation of ATs and exacerbate high-calorie diet-induced insulin resistance in mice92. Here, ACE2 is linked to diabetes mellitus.