We noted that although BRCA1 mutant models were more sensitive to ART558 than either isogenic BRCA1 wild type cell lines or non-tumour breast epithelial cells (Fig. 3c), there was clearly a spectrum of responses, with SUM149 cells and Brca1Δ11 MEFs exhibiting modest sensitivity, when compared to, for example, COV362, MDA-MB-436 or RPE.BRCA1‒/‒cells (Fig. 3l and Supplementary Fig. 3i). Here, BRCA1 is linked to neoplasm.