In parallel, we also used a publicly available CRISPR-Cas9 screen dataset26 to confirm the dependency of CAPAN1 cells upon POLQ. Using POLQ CERES scores27 we found that among 249 tumour cell lines tested, CAPAN1 cells were among the most sensitive, as were a number of BRCA1-mutant tumour cell lines (Supplementary Fig. 1c). Here, BRCA1 is linked to neoplasm.