To confirm the causative relationship between BRCA2 status and ART558 sensitivity, we also assessed ART558 sensitivity in a previously described PARP inhibitor resistant (Supplementary Fig. 1b) CAPAN1 daughter tumour cell clone that possesses a reversion mutation that restores the native open-reading frame of BRCA2, CAPAN1Revertant 24. The gene discussed is PARP1; the disease is neoplasm.