AKT1 and Huntington disease: To investigate whether pharmacological inhibition or activation of the PI3K-AKT pathway regulates the effects of MФs on megakaryopoiesis, primary human BM MФs from HD were treated with the PI3K-AKT pathway inhibitor LY294002 or activator 1,3-diCQA and then direct-contact coculture experiments were performed.