To investigate whether activating the PI3K-AKT pathway enhances the megakaryopoiesis-supporting ability of BM MФs from PT patients, BM CD34+ cells from HD were cocultured with PT MФs treated with 1,3-dicaffeoylquinic acid (1,3-diCQA) or YS-49 (PI3K-AKT pathway activators). This evidence concerns the gene AKT1 and Huntington disease.