To further correlate between MDP and macrophages supporting metastasis in human samples, we analyzed bulk RNA-seq from patients with breast carcinoma using the METABRIC data set.34 A moderate, positive correlation (r=~0.4–0.5) was found between IL-6 expression and the molecular signature of M2 macrophages (CD163, CD204, CD206, CD200R1, TGM2, IL1R2), whereas little correlation was found with an M1 gene signature (CD64, MHCII, CD86, CD80, CD68, NOS2) (figure 6E). The gene discussed is NOS2; the disease is breast carcinoma.