Furthermore, to strengthen the involvement of IL-6 in met-high tumors, transcription signatures of CD45+ stroma cells obtained from the tumor microenvironment of B16 melanoma, assessed by NanoString approach, revealed seven upregulated genes, including THBS1, MAPKAPK2, CD9, TXNIP, CD24, ITGA5, and SYK (online supplemental figure S5D). The gene discussed is SYK; the disease is melanoma.