IL6 and neoplasm: The IL-6/IL-6Ra pathway is often hyperactivated in many types of cancer41 and plays a key role in proliferation, survival, and invasiveness of tumor cells.42 43 In addition, it has been shown that IL-6 mediates metastatic mechanisms such as stimulation of epithelial-to-mesenchymal transition44 and induction of matrix metalloproteinases.45 Our study, however, provides another role for IL-6 in metastasis.