In this proof-of-concept analysis assessing the use of a simple whole blood assay to measure SARS-CoV-2-specific T-cell responses in a small HCW cohort, we show that SARS-CoV-2-specific CD4 T-cells (expressing IFN-γ, TNF-α or IL-2) were easily detectable in all tested convalescent COVID-19 participants. Here, TNF is linked to COVID-19.