Moreover, clearance of these alterations from ctDNA has been associated with response to therapy and improved outcomes in numerous cancer types, including NSCLC with common EGFR-activating mutations E19del and L858R.26,27 In this study, the failure to reach undetectable levels of ctDNA in any patient following treatment corresponded to a lack of clinical or radiographic response to erlotinib and onalespib. Here, EGFR is linked to non-small cell lung carcinoma.