We next evaluated EZH2 expression by clinical outcomes and found both EZH2 mRNA and protein levels were significantly lower in the 29% of HGSOC with platinum resistance (Fig. 3B) and were significantly associated with RTT after adjustment for tumor purity, residual disease, and molecular subtype (mRNA P = 0.003, protein P = 0.03). This evidence concerns the gene EZH2 and neoplasm.