In the present work we investigated (i) expression pattern of AXL-RTK in NB4 cells (ii) role of AXL-RTK in the proliferation potential of NB4-sensitive and resistant cells (iii) role of AXL-RTK in the regulation of Wnt/β-catenin signalling in APL. The gene discussed is AXL; the disease is acute promyelocytic leukemia.