AXIN2 and acute promyelocytic leukemia: Our findings indicate that the pharmacological targeting of AXL-RTK suppresses the proliferation of NB4 cells which is related to down-regulation of several Wnt/β-catenin target genes including c-myc, AXIN2 and HIF1α, suggesting the role of AXL-RTK in the regulation of Wnt/β-catenin pathway in APL.