It has fascinated researchers since its identification as the cause of a variety of neurodegenerative disorders including Creutzfeldt Jakob disease (CJD) in humans, scrapie in sheep, chronic wasting disease (CWD) in cervids and bovine spongiform encephalopathy (BSE) in cattle via a conformational change in PrPC to become scrapie prion protein, or PrPSc [1,2]. The gene discussed is PRNP; the disease is scrapie.