Our prioritization of ApoB as the most important lipoprotein-related risk factor for CAD is consistent with recent MR studies establishing ApoB as the primary risk factor for CAD.15,16 We also identified a modest but significant association between Lp(a) and PAD that was independent of ApoB, consistent with previous MR studies linking Lp(a) to CAD.28,36 In the setting of strong epidemiological and genetic correlation between CAD and PAD, it is not surprising that these 2 manifestations of ASCVD share ApoB and Lp(a) as common risk factors. This evidence concerns the gene APOB and atherosclerosis.