As a comparison, the association of genetically proxied ApoB lowering with CAD risk using the same genetic variants was greater (OR, 0.66 per 1-SD decrease in circulating ApoB [95% CI, 0.63–0.69], P=4×10−73; ratio of effects, 3.09 [95% CI, 2.29–4.60], P<1×10−6). The gene discussed is APOB; the disease is coronary artery disorder.