Consistent with the overall polygenic analysis, genetically proxied ApoB lowering at the ABCG5, PCSK9, APOB, LDLR, and ANGPTL8 loci had significantly greater protective effects on CAD compared with PAD (ratio of effect estimates >1, FDR <0.05; Figure 3C). Here, ANGPTL8 is linked to coronary artery disorder.