In the polygenic analysis, ApoB lowering proxied by genetic variants located within or near XS.VLDL.P–associated genes was associated with a reduced risk of PAD (OR, 0.89 per 1-SD reduction in ApoB [95% CI, 0.86–0.92]; P=3×10−11; Figure 4 and Table XVII in the Data Supplement). Here, APOB is linked to peripheral arterial disease.