LPA and peripheral arterial disease: In MR analyses, increases in genetically predicted Lp(a) were associated with increased risk of PAD [OR, 1.04 per 10–mg/dL increase in Lp(a) [95% CI, 1.03–1.04]; P=3×10−32], and the effect appeared linear across the range of Lp(a) (Table XIX and Figure I in the Data Supplement).