Furthermore, numerous markers of organ dysfunction (cardiac: NT-proBNP, troponin T; renal: creatinine, urea; liver: aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, and total bilirubin) and, inversely, markers of anemia (hemoglobin, erythrocytes, and hematocrit) were correlated with the WHO grade of the patient. This evidence concerns the gene NPPB and anemia (phenotype).