The observation that the PDS gene Signature-3 score is higher in TCGA breast tumors with somatic damaging mutations of BRCA1 gene (Supplementary Table S3) might suggest that deficiency in homologous recombination pathway may lead to high micronuclei accumulation as observed previously in osteosarcoma U2OS cancer cells (12). The gene discussed is BRCA1; the disease is breast neoplasm.