Nevertheless, an increase in Calreticulin and Grp94 transcription (Fig 2E) was observed in tunicamycin-treated cells (red circles) and to a greater extent in MHV-infected cells (blue squares) especially at 8 h p.i. This indicates that the ATF6 pathway is highly up-regulated during MHV-infection. The gene discussed is HSP90B1; the disease is infection.