CXCL8 and infection: Notably, (1) and(R)-6 were equally efficient but morepotent than Dex in enhancing LPS-inducedrelease of IL-8 by 2.5-fold (Figure S3).IL-8 has long been recognized to have both pro- and anti-inflammatoryactivities, which has been established in various models of infection,inflammation, and cancer.63 IL-8 is knownto inhibit leukocyte adhesion to activated endothelial cells and thusexhibits anti-inflammatory properties.