TNF and atherosclerosis: vSMC-monocytecross-talk is a key driver of inflammation associated with atherosclerosis.54 We evaluated the impact of (R)-6 on TNF-α-stimulated NF-κB in culturedmouse primary vSMCs, as previously described,18 by transfecting SMCs with an NF-κB reporter plasmid (pNF-κB-SEAPvector) for 24 h and subsequently stimulating SMCs with TNF-α(1 ng/mL) for 24 h in the presence or absence of a vehicle or (R)-6 (1 nM).