Peripheral monocytes, TAM predecessors, are recruited into the tumor lesions through the engagement of CSF1/CSF1R [313] and CCL2/CCR2 [310]; hence, the blockade of these factors might potentially reduce the accumulation of TAMs in tumors, thereby overcoming the TAM-related immunosuppression and enhancing tumor-specific T cell responses. Here, CCL2 is linked to neoplasm.