PLAU and neoplasm: Beyond that, TAMs can produce matrix metalloproteases (e.g., MMP2 and MMP9) and factors (e.g., TGF-β, PDGF, IL-6, urokinase plasminogen activator (u-PA), and tissue-type plasminogen activator (t-PA)) to degrade the ECM for tumor invasion and migration [268, 269].