M1-type macrophages secreting immunogenic cytokines, such as IL-12 and TNF-a, improve the immune response that exerts inhibitory effects on tumor growth, and M2-type macrophages secreting immunosuppressive cytokines, such as IL-10 and TGF-β, impair antitumor immunity to enhance tumor growth [16, 17]. The gene discussed is TNF; the disease is neoplasm.