For example, Chen et al. have reported a thermo-sensitive hydrogel co-loaded DOX/IL-2/IFN-γ, which showed improved therapeutic efficacy B16F10 melanoma tumor by enhancing tumor cell apoptosis and increasing proliferation of the CD3+/CD4+ T cells and CD3+/CD8+ T cells [151]. The gene discussed is IFNG; the disease is neoplasm.