Studies have shown that chemotherapeutics could enhance intrinsic immunogenicity of tumor cells by upregulating the expression of tumor antigens [72] and MHC-I [73], inducing the expression of costimulatory molecules [74], downregulating the immune checkpoint molecules expressed on the tumor cell surface [75], inducing tumor cell death by secreting ATP or expressing calreticulin [68] and so on [76, 77]. Here, CALR is linked to neoplasm.