Compared with PTX-loaded spherical Eu particles (Eu-s/PTX), Eu-FBCP/PTX nanosystems augmented the cellular uptake into MC-38 cells through both phagocytic and micropinocytic pathways, accelerated cell cycle arrest in G2/M phase, enhanced the apoptosis of cancer cells via the intrinsic apoptotic pathway, and induced high levels of HMGB1 secretion and CRT exposure, resulting in the greater induction of ICD that triggered the maturation of DCs and activation of cluster of differentiation (CD)8+T cells. Here, CALR is linked to cancer.