Multiple IL-17 receptors (IL-17 ra, IL-17 rb, IL-17 rc, and IL-17 re) are expressed on astrocyte membranes; therefore, IL-17 has been shown to exert a strong influence on astrocytes in the central nervous system, especially in ischemia, inflammation, and degenerative diseases [41]. The gene discussed is IL17A; the disease is neurodegenerative disease.