Some of the differences between the GR-ER and GR-AR crosstalk may, however, derive from cell models: MCF-7 cells that endogenously express both ER and GR were used as the model for BCa experiments (West et al. 2016), but most PCa experiments were performed in LNCaP-1F5 cells expressing endogenous AR and rat GR from an engineered, integrated gene (Sahu et al. 2013). The gene discussed is NR3C1; the disease is posterior cortical atrophy.