LDHC and pancreatitis: I. The alanine-to-lactate signal ratio decreases progressively from the normal pancreas to pancreatitis to low-grade PanINb to high-grade PanIN to PDAC, using HP-MRII. Holds true for individual mice with time as well as upon comparing the three groups, considering their genetic proximity to PDAC (I>II>III)III. Caused by increasing LDHc activity and decreasing ALTd activity