However, selectivein vivo imaging of CYP11B2 has not yet been achieved due to the closehomology between the enzymes involved in aldosterone (CYP11B2) andcortisol (CYP11B1) synthesis.11−18 This is a major limitation as CYP11B1 is highly expressed in healthyadrenals and some adenomas, without any apparent correlation withthe rate of aldosterone excretion. Here, CYP11B1 is linked to adenoma.