The purpose of this study was tosynthesize a fluorine-18 labeled,highly selective aldosterone synthase (hCYP11B2)inhibitor, [18F]AldoView, and to assess its potential forthe detection of aldosterone-producing adenomas (APAs) with positronemission tomography in patients with primary hyperaldosteronism (PHA).Using dibenzothiophene sulfonium salt chemistry, [18F]AldoViewwas obtained in high radiochemical yield in one step from [18F]fluoride. The gene discussed is CYP11B2; the disease is Pelger-Huet anomaly.