Twenty percent of HCM cases and eight% of DCM cases had pathogenic variants for cardiomyopathy, while 31% of HCM cases and 22% of DCM cases remain unexplained by having likely benign variant(s) or having no variants detected in any of the analysed genes.We replicated at least four recurrent variants among cardiomyopathy patients, which could be founder disease mutations in the Arabic population, including a frameshift variant (c.1371_1381dupTATCCAGTTAT) in the FKTN gene which seems to cause DCM in homozygosity and HCM, in heterozygosity. The gene discussed is FKTN; the disease is cardiomyopathy.