Conversely, overexpression of miR‐126 by transfection of miR‐126 mimic into SSc‐MVECs dramatically increased ERK1/2 phosphorylation and AKT phosphorylation in response to VEGF by approximately 2.5 folds compared to a microRNA mimic control (Figure 5E‐F). The gene discussed is MAPK3; the disease is systemic sclerosis.