Increased mRNA expression levels of SRED1 by 2.54 ± 0.22 folds and PIK3R2 by 3.42 ± 0.34 folds in SSc‐MVECs were noted, compared with the normal control (Figure 2B; P < 0.01) in association with reduced expression of miR‐126 in SSc‐MVECs (Figure 2B). Here, PIK3R2 is linked to systemic sclerosis.