Previous studies reported that transcription factors binding to these sites are essential for the transcriptional regulation of EGFL7,26, 27, 28, 29 and therefore, the methylation of these sites of the promoter region can hinder transcriptional factor binding and repress the transcription of EGFL gene and miR‐126 gene in SSc‐MVECs.30 This evidence concerns the gene EGFL7 and systemic sclerosis.