To examine the responses of MVECs to VEGF‐induced angiogenesis, NL‐MVECs and SSc‐MVECs were plated onto Matrigel to investigate capillary tube assembly and plated into fibronectin‐coated 6‐well plates and Corning FluoroBlokTM 96‐well insert to test MVEC migration. This evidence concerns the gene FN1 and systemic sclerosis.