SLC12A5 and brain disorder: Moreover, similar variations in the Cltransporters’ ratio (due either to higher expression of NKCC1and/or to lower expression of KCC2) were observed in several otherbrain disorders, both in human samples and in animal models.1,2,4 These alterations lead to an increased[Cl–]i in neurons, which in turn affectsthe neuronal function in brain disorders.1