AKT1 and sarcoma: The two key signalling pathways associated with HER2 oncogenic properties are the rat sarcoma/mitogen-activated protein kinase (RAS/MAPK) pathway and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway (Aksamitiene et al.2012; Yang et al. 2016; Ruiz-Saenz et al. 2018).