In this context, Braak and colleagues have reported that in a subset of PD cases, pathological aSyn lesions are detected in the lamina I and autonomic nuclei in the thoracic cord, although the authors implicated the enteric nervous system as the site of origin50 and (ii) White matter aSyn pathology in the CNS: Our data (Fig. 4) highlight the ancillary affection of the white matter tracts, and significant oligodendroglial aSyn pathology in the M83+/+ model. The gene discussed is PGAP6; the disease is Parkinson disease.