Although the gross appearance of p-aSyn (S129) lesions in the CNS of M83+/+ model reflects some degree of resemblance to Lewy related aSyn pathology in human tissue specimen, these data should be interpreted with caution and require further systematic analyses to establish the relevance of this feature to synucleinopathies (see Limitations of the model, in Discussion). This evidence concerns the gene PGAP6 and synucleinopathy.