To explain these unexpected results, Wec et al. (Wec et al., 2020) suggested that most of these NmAbs result from preexisting memory B cells induced through infection by other circulating HCoVs strains, as HCoV S proteins resemble up to 32% the SARS-CoV and SARS-CoV-2 S proteins. The gene discussed is PROS1; the disease is infection.