Our previous study screened and evaluated the differential mRNA expression and altered methylation levels of nine aging-related genes (AREG, ATG3, E2F1, FOXO3, HDAC1, MMP2, NUF2, TGFB1, and TP53) in COPD patients (Du et al., 2019). This evidence concerns the gene TP53 and chronic obstructive pulmonary disease.