AREG, E2F1, FOXO3, HDAC1, MMP2, TGFB1, and TP53 have been confirmed as crucial signaling molecules in asthma (Enomoto et al., 2009; Nakagome and Nagata, 2011; Butler et al., 2012; Xu, 2014; Toujani et al., 2016; Amarin et al., 2017; Hur and Broide, 2019; Wang et al., 2019). The gene discussed is TP53; the disease is asthma.