The two scores in common use are the juvenile arthritis disease activity score (JADAS) which measures four domains including physician global assessment, patient global assessment, active joint count, and an inflammatory marker (either CRP or ESR) (115) and the core outcome variables which include a physician global assessment, patient/ parent global assessment, functional status, inflammatory marker (ESR), number of joints with active arthritis, and number of joints with restricted range of movement (116). This evidence concerns the gene CRP and Arthritis.