Similarly, flaccidoxide-13-acetate, isolated from cultured soft coral Sinularia gibberosa, was found to provoke ERS and activate the PERK–eIF2α–ATF6–CHOP pathway, causing inhibitory effects against the invasion and migration of bladder cancer cells (Wu et al., 2019b). This evidence concerns the gene EIF2AK3 and urinary bladder carcinoma.