Arctigenin (Kim et al., 2010), 11-epi-sinulariolide acetate (Lin et al., 2016), and flaccidoxide-13-acetate (Sinclair, 1988) have been proved to kill colon, cervical, or bladder cancer cells through the activation of the PERK/eIF2α/ATF4/CHOP pathway. This evidence concerns the gene EIF2AK3 and urinary bladder cancer.