However, in the U87 glioblastoma cell line and SKBR3 breast cancer cell line, the activation of PI3K/AKT leads to the inactivation of PERK and its downstream eIF2α, thereby inhibiting the protective effect of PERK/eIF2α on tumor cells (Mounir et al., 2011). The gene discussed is EIF2AK3; the disease is breast cancer.