CDKN1C and nasopharyngeal carcinoma: Several studies have also shown that EZH2 can promote cell proliferation by inhibiting cyclin-dependent kinase (CDK) inhibitor 1C (CDKN1C) (Yang et al., 2009), which is inactivated by promoter DNA methylation in several human tumors (McGarvey et al., 2006; Fang et al., 2021), thereby promoting nasopharyngeal carcinoma development and increasing the malignancy of nasopharyngeal carcinoma cells (Meng et al., 2020).