YTHDC2 expression is significantly correlated with B cells, CD4+T cells, neutrophils, and dendritic cells, but not with macrophage infiltration in HNSCC (Li et al., 2020), indicating that YTHDC2 may play an important role in immune cells in the tumor microenvironment, especially CD4+T cells and dendritic cells. Here, YTHDC2 is linked to head and neck squamous cell carcinoma.