PTEN and acute myeloid leukemia: In acute myeloid leukemia (AML), m6A upregulates the expression of the MYB proto-oncogene, MYC proto-oncogene, BCL2, phosphatase and tensin homolog, and SP1 transcription factor, which in turn enhance the binding ability and translation efficiency of the oncogenic RNA and ribosome to facilitate tumorigenesis (Li et al., 2017b; Wang et al., 2020a; Qing et al., 2021; Yankova et al., 2021).