Depletion of TNFAIP1 results in RhoB accumulation and expression of pro-inflammatory IL-6 and IL-8 genes, suggesting that the Cullin3-TNFAIP1-RhoB axis controls inflammatory response in hepatocellular carcinoma cells (Liu et al., 2021; Figure 1C). The gene discussed is TNFAIP1; the disease is hepatocellular carcinoma.