TRG-AS1 and metastatic malignant neoplasm in the lymph nodes: Overexpression of TRG-AS1 is associated with advanced TNM stage, lymph node metastasis, and shorter overall survival, which promotes cell proliferation, invasion, and migration of TSCC (tongue squamous cell carcinoma) by mediating the miR543/YAP1 axis (He et al., 2020).