CD200 interacts with its receptor CD200R1 to trigger immunosuppressive signals, resulting in macrophage suppression, regulatory T cell induction, cytokine profile switching from Th1 to Th2, and finally the inhibition tumor-specific T-cell immunity (Gorczynski et al., 1999; Vaine and Soberman, 2014). Here, CD200 is linked to neoplasm.