Chun et al. showed that Lcn2 expression increases in the optic nerve astrocytes of experimental autoimmune optic neuritis (EAON) model and that optic neuritis features such as demyelination and gliosis are reduced in EAON-induced Lcn2 knockout mice (Chun et al., 2015). The gene discussed is LCN2; the disease is autoimmune optic neuritis.