In experimental emphysema induced by cigarette smoke, bone marrow-derived MSCs (BM-MSCs), which can be chemoattracted to sites of injury by inflammatory chemokines and by matrikines—e.g., collagen present in the ECM that can induce higher adhesion, survival and proliferation of MSCs (Somaiah et al., 2015), as well as elastin fragments that promote higher MSC adhesion (Jin et al., 2016), reduced cell apoptosis counts and levels of pro-inflammatory mediators and proteases in lung tissue (Guan et al., 2013). This evidence concerns the gene ELN and pulmonary emphysema.