DSCAM and Hirschsprung disease: In 2013, an association analysis with 10,895 single-nucleotide polymorphisms (SNPs) in 26 Caucasian DS HSCR cases and their parents identified two associated SNPs (rs2837770 and rs8134673) in intron 3 of DSCAM, and the results were replicated in 220 Caucasian cases with isolated HSCR and their parents (Jannot et al., 2013).