TAMs are also broken down into subsets based on polarization to the M1 macrophage-like phenotype (pro-inflammatory/anti-tumor) CD68+ CD80/86+ CD11c+ iNOS+ and the M2 macrophage-like phenotype (pro-tumor) CD163+ CD204+ CD206+ Arg1+, with M2-like TAMs being the most immunosuppressive (41, 42). The gene discussed is CD80; the disease is neoplasm.