For TAMs, this includes producing anti-inflammatory mediators such as IL-10, Arg1, and TGF-β (56–58), promoting the expression of checkpoint inhibitors to suppress T cells (56, 57), inducing cancer stem cell proliferation via IL-6 signaling through STAT3 (59), and producing VEGF to stimulate angiogenesis (60, 61). This evidence concerns the gene IL6 and cancer.