Via tail injecting of liver specific NMT1 expressing plasmids in NMT1 knock-out mice, we generated the NMT1 rescue mice (NMT1−/−+NMT1, NMT1flox/flox: Alb-Cre+NMT1), and expectedly, larger and more tumor loci could be detected in the liver of this kind of mice compared to the NMT1 knock-out mice (Figure 1E), suggesting liver tumorigenesis is indispensible of NMT1. The gene discussed is NMT1; the disease is neoplasm.